达克利司是咪唑喹啉衍生物, 是一种双重的 pan-class I PI3K 和 mTOR 抑制剂,作用于 p110α/γ/δ/β 和 mTOR,IC50 分别为 4 nM/5 nM/7 nM/75 nM 和 20.7 nM,抑制 mTORC1 和 mTORC2.
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