三氟甲基是具有通式-CF3的官能团.基团的命名来源于甲基（它具有通式-CH3）,用氟原子取代每个氢原子.一些常见的例子是三氟甲烷H-CF3,1,1,1-三氟乙烷H3C-CF3,和六氟丙酮F3C-CO-CF3.具有该基团的化合物是有机氟的亚类.
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