立他司特是整合素淋巴细胞功能相关抗原-1(LFA-1)的拮抗剂, 抑制Jurkat T细胞附着于ICAM-1的IC50为2.98nM,FDA批准的药物用于干眼的症状和体征的综合征的治疗,称为干燥性角结膜炎,通过抑制炎性细胞结合减少炎症.它经常被用来与环孢素（ikervis或restasis）干眼症的治疗包括睑板腺功能障碍和炎症性干眼.
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