莫替沙尼是一种有效的 VEGFR1/2/3 的 ATP 竞争性抑制剂,IC50 值为 2 nM/3 nM/6 nM,与对Kit的选择性相似,是 PDGFR 和 Ret的 10 倍多,是一种口服给药的小分子,属于血管激酶抑制剂类,其作为VEGF受体、血小板衍生生长因子受体和干细胞因子受体的拮抗剂.它被用作磷酸盐莫替尼布二磷酸盐.在对甲状腺癌、非小细胞肺癌、胃肠道间质癌、大肠癌和乳腺癌进行临床试验后,发现该药物没有显示出足够的疗效以进一步发展,并且开发被Takeda放弃.
-
≥97% CAS No.:10403-47-1 -
SKU-Pack Size Availability Price（￥） Quantity R100467-1g In-Stock(Shanghai or CA Irwindale) R100467-5g In-Stock(Shanghai or CA Irwindale) R100467-5g In-Stock(Shanghai or CA Irwindale) R100467-25g In-Stock(Shanghai or CA Irwindale) R100467-100g In-Stock(Shanghai or CA Irwindale) R100467-1g In-Stock(Shanghai or CA Irwindale) R100467-5g In-Stock(Shanghai or CA Irwindale) R100467-25g In-Stock(Shanghai or CA Irwindale) R100467-100g In-Stock(Shanghai or CA Irwindale) R100467-1g In-Stock(Shanghai or CA Irwindale) R100467-10g In-Stock(Shanghai or CA Irwindale) R100467-25g In-Stock(Shanghai or CA Irwindale) R100467-100g In-Stock(Shanghai or CA Irwindale) R100467-500g In-Stock(Shanghai or CA Irwindale)