来那度胺是一种有效的 TNF-α 抑制剂,具有抗血管增生作用.Lenalidomide 作为连接酪蛋白激酶 1A1 (CKIα) 与人 E3 连接酶 cereblon 的蛋白质稳态调节剂 (PHM) 起作用.最初被认为是治疗多发性骨髓瘤,沙利度胺是一种公认的治疗方法.来那度胺也显示出一类血液系统疾病的有效性,称为骨髓增生异常综合征（MDS）.
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