克罗拉滨能抑制核苷酸还原酶,IC50为65 nM,还能抑制DNA聚合酶活性,是嘌呤核苷抗代谢产物.在至少两种其他类型的治疗已经失败后,这是FDA批准的治疗儿童复发或难治性急性淋巴细胞白血病（ALL)的药物.
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