卡博替尼是一种有效的多受体酪氨酸激酶抑制剂, 抑制VEGFR2,c-Met,Kit,Axl 和 Flt3 的 IC50 分别为0.035,1.3,4.6,7 和 11.3 nM,是用于治疗甲状腺髓样癌的药物,也是肾细胞癌的第二线治疗药物.它是酪氨酸激酶c-Met和VEGFR2的小分子抑制剂,对AXL和RET也有抑制作用.
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