硼替佐米是有效的 20S 蛋白酶体 (20S proteasome) 抑制剂,Ki 为 0.6 nM,是一种抗肿瘤药物,是人类应用的第一种治疗性蛋白酶体抑制剂.蛋白酶体是分解蛋白质的细胞复合物.在一些癌症中,通常杀死癌细胞的蛋白质被分解得太快.硼替佐米阻断了这一过程,并让这些蛋白质杀死癌细胞.在美国和欧洲被批准用于治疗复发性多发性骨髓瘤和套细胞淋巴瘤.
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