聚乙二醇化(通常称为聚乙二醇化)是聚乙二醇(PEG)聚合物链与分子、大分子结构(如药物、治疗蛋白或囊泡)共价和非共价结合或合并的过程,然后称为PEGy.羽化（聚乙二醇化）.PEG化通常是通过将PEG的反应性衍生物与目标分子孵育而实现的.PEG与药物或治疗性蛋白质的共价结合可以“掩盖”病原体不受宿主免疫系统的影响（降低免疫原性和抗原性）,并增加其流体力学大小（溶液中的大小）,从而通过减少肾脏清除来延长其循环时间.聚乙二醇化还可为疏水性药物和蛋白质提供水溶性.
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